Cancer Science & Therapy

Antúnez JR

Publications

• Research Article
  Pancreatic Ductal Adenocarcinoma: Implications of Epigenetic Role Related the Src Pathway
  Author(s): Padin-Iruegas ME, Eugenyeva E, Herranz-Carnero M, Aguín Losada S, Brozos Vázquez E, Abdullkader I, Antúnez JR, Ruibal-Morell A and López-López RPadin-Iruegas ME, Eugenyeva E, Herranz-Carnero M, Aguín Losada S, Brozos Vázquez E, Abdullkader I, Antúnez JR, Ruibal-Morell A and López-López R
  
  Epigenetic has become, in recent years, in a very important process in the control of several pathologies, including cancer. DNA methylation has been described in numerous studies as crucial for differentiation control, cell proliferation and invasion in cancer. Pancreas ductal adenocarcinoma is one of the most deadly diseases of our society; its complexity and variability have become one of the medical challenges of this decade. Combining the potential of epigenetic with the high mortality and the limited knowledge of pancreatic ductal adenocarcinoma origin, may result in new approaches for diagnosis, treatment and monitoring, crucial in this pathology. For this purpose, we analyzed genes involved in different cellular processes (GSTP1, p16, RASFF1A, RARβ2, CyclinD2, HIN-1, SOCS1, TIMP3, DAPK and TWIST1) in 61 cases of pancreatic ductal adenocarcinom.. Read More»
  DOI: 10.4172/1948-5956.1000247

  Abstract PDF