Journal of AIDS & Clinical Research

Antonella Mandas

Publications

• Research Article
  Determination of Neutral Lipid and Cluster Formation for Screening Neurocognitive Impairment in Human Immunodeficiency Virus Patients
  Author(s): Diego Costaggiu, Luca Serchisu, Claudia Abete, Elisa Pinna, Sarah Vascellari, Francesco Ortu, Paolo Emilio Manconi, Alessandra Pani and Antonella MandasDiego Costaggiu, Luca Serchisu, Claudia Abete, Elisa Pinna, Sarah Vascellari, Francesco Ortu, Paolo Emilio Manconi, Alessandra Pani and Antonella Mandas
  
  Objectives: Despite combination antiretroviral therapy (cART) introduction, human immunodeficiency virus (HIV) patients have increased risk for neurocognitive impairment (NCI). However, NCI assessment methods in these patients have limitations. Many neurocognitive screening tests, although quicker, identify only the most severe form of impairment and are not suitable for early neurological disorder detection. We previously stated that determination of neutral lipids (NLs) by oil red O (ORO) staining in the cytoplasm of unstimulated peripheral blood mononuclear cells (PBMCs), combined with their tendency to cluster formation (CF), may represent a novel non-invasive approach to detect and monitor neuronal injury in the disease’s early stages. In an attempt to find rapid, feasible tools to screen for NCI in HIV patients, we determined ORO staining and CF in unstimu.. Read More»
  DOI: 10.4172/2155-6113.1000517

  Abstract PDF