Journal of Nephrology & Therapeutics

Antonia Bouts

Publications

• Case Report
  Hemolytic Uremic Syndrome in Post-Infectious Glomerulonephritis: Possible Pathophysiological Mechanisms
  Author(s): Jean-Claude Davin, Jaap W. Groothoff, Michiel Oosterveld, Rixt Schriemer, Nicole van de Kar, Antonia Bouts and Sandrine FlorquinJean-Claude Davin, Jaap W. Groothoff, Michiel Oosterveld, Rixt Schriemer, Nicole van de Kar, Antonia Bouts and Sandrine Florquin
  
  Malignant hypertension is able to induce glomerular Thrombotic Microangiopathy (TMA) and Hemolytic Uremic Syndrome (HUS) in the absence of Glomerulonephritis (GN). It is therefore commonly admitted that hypertension is the only cause of Glomerular Endothelial Cells (GEC) damage leading to TMA and HUS observed in GN. However, recent literature on TMA in IgA nephropathy calls this hypothesis into question. It is also questionable why so few cases of HUS are reported in association with Post-Infectious GN (PIGN) for which more than 50% of cases necessitate anti-hypertension treatment, we report the case of a 10 years old girl presenting with an extensive cutaneous streptococcal infection, hematuria, nephrotic syndrome, hypertension (146/106) and HUS needing dialysis. The kidney biopsy revealed a severe exudative GN, 30% of crescentic glomeruli and TMA. Immunofluorescence and electron mic.. Read More»
  DOI: 10.4172/2161-0959.S11-008

  Abstract PDF