Journal of Computer Science & Systems Biology

Archana Jayaraman

Publications

• Research Article
  Homology Modelling and Docking Studies of Human α2-Adrenergic Receptor Subtypes
  Author(s): Archana Jayaraman, Kaiser Jamil and Kavita K KakaralaArchana Jayaraman, Kaiser Jamil and Kavita K Kakarala
  
  α2-adrenergic receptors play a key role in the regulation of sympathetic system, neurotransmitter release, blood pressure and intraocular pressure. Although α2-adrenergic receptors mediate a number of physiological functions in vivo and have great therapeutic potential, the absence of crystal structure of α2-adrenergic receptor subtypes is a major hindrance in the drug design efforts. The therapeutic efficacy of the available drugs is not selective for subtype specificity (α2a, α2b and α2c) leading to unwanted side effects. We used Homology modelling and docking studies to understand and analyze the residues important for agonist and antagonist binding. We have also analyzed binding site volume, and the residue variations which may play important role in ligand binding. We have identified residues through our modelling a.. Read More»
  DOI: 10.4172/jcsb.1000111

  Abstract PDF