Brazil
Research Article
Molecular Modeling of Heat Shock Protein of 60-Kda from Paracoccidioides Brasiliensis: The First in silico Structural Model of a Fungal Hsp60
Author(s): Fabrício Freitas Fernandes, Renata Ariza Marques Rossetti, Arlete Coelho-Castelo and Ademilson Panunto-CasteloFabrício Freitas Fernandes, Renata Ariza Marques Rossetti, Arlete Coelho-Castelo and Ademilson Panunto-Castelo
Paracoccidioides brasiliensis is a dimorphic fungus that causes paracoccidioido mycosis (PCM), an endemic mycosis in Latin America. PCM is a chronic, granulomatous, and progressive disease, which has a wide clinical spectrum of manifestations. Although it knows that the main clinical forms are consequences of fungus-host interaction, immune response in PCM is still an open field. The antigenic complexity of P. brasiliensis and the role of most antigens have been poorly explored, thereby decreasing the chances of finding vaccine and therapeutic targets for PCM. Recent results from our group have shown that heat shock protein of 60-kDa from P. brasiliensis strain 18 (Hsp60_Pb18) has a possible detrimental effect on the course of the PCM. Here, we show the molecular model of Hsp60_Pb18 that was generated with the program MODELLER9V8. The model validation was performed us.. Read More»
DOI:
10.4172/jcsb.1000164
Journal of Computer Science & Systems Biology received 2279 citations as per Google Scholar report