Metabolomics:Open Access

Arthur RA

Publications

• Research Article
  A Potential Biofilm Metabolite Signature for Caries Activity - A Pilot Clinical Study
  Author(s): Zandona F, Soini HA, Novotny MV, Santiago E, Eckert GJ, Preisser JS, Benecha HK, Arthur RA and Zero DTZandona F, Soini HA, Novotny MV, Santiago E, Eckert GJ, Preisser JS, Benecha HK, Arthur RA and Zero DT
  
  Background: This study’s aim was to compare the dental biofilm metabolite-profile of caries-active (N=11) or caries-free (N=4) children by gas chromatography-mass spectrometry (GC/MS) analyses. Methods: Samples collected after overnight fasting, with or without a previous glucose rinse, were combined for each child based on the caries status of the site, re-suspended in ethanol and analyzed by GC/MS. Results: Biofilm from caries-active sites exhibited a different chromatographic profile compared to caries-free sites. Qualitative and quantitative analysis suggested a special cluster of branched alcohols and esters present at substantially higher intensity in biofilms of caries-active sites. Conclusions: This pilot study indicates that there a.. Read More»
  DOI: 10.4172/2153-0769.1000140

  Abstract PDF