Cancer Science & Therapy

Ashok K Varma

Publications

• Research Article
  Pathogenicity of Mutations Discovered in BRCA1 BRCT Domains is Characterized by Destabilizing the Hydrophobic Interactions
  Author(s): Dilip C Badgujar, Ulka Sawant, Hafiza Mahadik, Nikhil Gadewal and Ashok K VarmaDilip C Badgujar, Ulka Sawant, Hafiza Mahadik, Nikhil Gadewal and Ashok K Varma
  
  Background: Breast and ovarian cancer are the most common cancers among hetrogenetically diversified women. It is quite difficult to categorize the population at a high risk of breast cancer using peer genetic information because one particular mutation can be found in the same or in different families. Several mutations have been discovered across the full length of BRCA1 gene, and categorizing their pathogenicity is a major challenge. Carriers of BRCA1 mutations have an increased risk of developing cancer. In the breast cancer database BIC, approximately 1,500 genetic variants have been reported. It is very difficult to characterize each of the reported mutations. Given the complexities in characterizing the mutations, we decided to investigate functional basis associated with the mutations, rather than looking at each mutation. Materials and methods.. Read More»
  DOI: 10.4172/1948-5956.1000172

  Abstract PDF