Human Genetics & Embryology

Atiba AA

Publications

• Research Article
  Assessment of Chromosomal Aneuploidy in Day 3 Cleavage-Stage Embryos and Day 5/6 Blastocysts from Indigenous Black Africans
  Author(s): Ajayi AB, Ajayi VD, Atiba AA, Oyetunji IO, Ehichioya J, Ayelehin IB, Adeoye AT, Adesida TE and Afolabi BMAjayi AB, Ajayi VD, Atiba AA, Oyetunji IO, Ehichioya J, Ayelehin IB, Adeoye AT, Adesida TE and Afolabi BM
  
  The objectives of this study were to examine the prevalence and to characterize the types of chromosomal aberrations of aneuploidy in cleavage-stage Day 3 human embryos and in Day 5/6 human blastocysts in indigenous Black African women aged ≤ 35 and >35 years. Of the 312 oocytes fertilized for Day 3 embryos and 269 for Day 5/6 blastocysts, 230 blastomeres and 122 blastocysts were biopsied respectively and then subjected to genetic analysis using the array CGH and next generation sequencing methods, genotyping to characterize chromosomal error types of aneuploidy across all 24 chromosomes. A total of 562 oocytes with 486 MII oocytes, were fertilized from which 230 Day 3 embryos and 122 Day 5/6 blastocysts were biopsied. Euploidy rates in Day 3 embryo group and in Day 5/6 blastocyst group were 24.3% and 75.0% respectively while aneuploidy rates were 75.7% and 25.0% respectively.. Read More»
  DOI: 10.4172/2161-0436.1000147

  Abstract PDF