Journal of Hypertension: Open Access

Aubdool-Essackjee

Publications

• Review Article
  Angiotensin-II Induced Reactive Oxygen Species: Implications in Neurogenic Hypertension
  Author(s): LU Chengzhi, WANG Li, Aubdool-Essackjee, Nima Sherpa and LUO DiLU Chengzhi, WANG Li, Aubdool-Essackjee, Nima Sherpa and LUO Di
  
  Reactive oxygen species (ROS) play an important role in the development and maintenance cardio vascular diseases, especially hypertension. The relationship between ROS and hypertension has been demonstrated in several models of experimental hypertension. Accumulating evidence has suggested that the key mechanism through which Angiotensin II (Ang II) influences blood pressure is via its ability to activate ROS signaling pathways. Ang II, by stimulating angiotensin AT1 receptors, involved in the activation of NAD(P)H oxidase, which is a major source of ROS production. Despite many elegant studies that have been accumulated regarding ROS/Ang II signaling, there is still much to be elucidated in the role of ROS in neurogenic hypertension. The present review mainly discussed some recent findings documenting about the signaling mechanisms of Ang II-induced ROS in neurogenic hypertensi.. Read More»
  DOI: 10.4172/2167-1095.1000106

  Abstract PDF