Cancer Science & Therapy

Aubrey Knavel

Publications

• Research Article
  Induction of Differential Growth in vitro by High-risk Human Papillomavirus in Human Breast Cancer Cell Lines is Associated with Caspase Dysregulation
  Author(s): Karl Kingsley, Jennifer Zuckerman, Morghan Davis, Matt Matteucci, Aubrey Knavel, Jacqueline Rinehart, Van Tran, Demian Woyciehowsky, Phillip Jenkins, Rui Yu, Dieu-Hoa Nguyen and Susan O’MalleyKarl Kingsley, Jennifer Zuckerman, Morghan Davis, Matt Matteucci, Aubrey Knavel, Jacqueline Rinehart, Van Tran, Demian Woyciehowsky, Phillip Jenkins, Rui Yu, Dieu-Hoa Nguyen and Susan O’Malley
  
  Introduction Many viruses have been associated with human breast cancers, including Epstein-Barr and Cytomegalovirus. New evidence has revealed the frequent presence of highrisk human papillomavirus (HPV) strains HPV16 and HPV18 in breast carcinoma biopsies. These findings raise the question of whether HPV may infect developing cancers and mediate their growth and development, as was recently observed with oral cancers. The goal of this study is to test the hypothesis that these high-risk HPV strains are sufficient to significantly alter phenotypes of already transformed human breast cancer cell lines. Materials and methods A series of in vitro experiments, including proliferation, adhesion and viability assays, were used to quantify the effects of HPV16 and HPV18 on the human breast cancer cell lines, T-47D and MCF7, following transient transfection with the full length HPV vir.. Read More»
  

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