Molecular Biomarkers & Diagnosis

Axel Semjonow

Publications

• Research Article
  GDF15 and Hepcidin as Prognostic Factors in Patients with Prostate Cancer
  Author(s): Franca Julia Winand, Martin Boegemann, Inka Gallitz, Lothar Hertle, Axel Semjonow, Maria Eveslage, Hugo Karel Van Aken, Edwin Herrmann and Andrea Ulrike SteinbickerFranca Julia Winand, Martin Boegemann, Inka Gallitz, Lothar Hertle, Axel Semjonow, Maria Eveslage, Hugo Karel Van Aken, Edwin Herrmann and Andrea Ulrike Steinbicker
  
  Background: Prostate Cancer (PCa) is a frequent malignancy worldwide. Prognosis of prostate cancer (PCa) is diverse with 80% not life-threatening even if untreated. In contrast, 20% are aggressive with short course of the disease. Hence the need for prognostic markers to predict aggressiveness, patients’ outcome, and efficacy of treatment is increasing. Methods: We retrospectively analyzed serum and demographic data from 38 PCa-patients. Serum growth differentiation factor 15 (GDF15), hepcidin and interleukin-6 (IL-6) were measured. Results: Serum GDF15 levels were higher in metastatic castration-resistant PCa patients with rapid disease progression than in metastatic PCa patients with slow disease progression. There was a trend to higher serum hepcidin - but not IL-6 - serum levels in patients with rapid dis.. Read More»
  DOI: 10.4172/2155-9929.1000199

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