Nuclear Medicine & Radiation Therapy

Ayaz Mahmood Dar

Publications

• Mini Review
  A Concise Review on the Synthesis of Pyrazole Heterocycles
  Author(s): Ayaz Mahmood Dar and ShamsuzzamanAyaz Mahmood Dar and Shamsuzzaman
  
  Study background: Pyrazole moiety, being called as pharmacophore, plays an important role in many biologically active compounds and therefore represents an interesting template for combinatorial as well as medicinal chemistry. In addition pyrazoles are also used extensively as useful synthons in organic synthesis. These derivatives have wide spread biological activities such as anticancer, analgesic, anti-inflammatory, antimicrobial, antiviral, anticonvulsant, antihistaminic and anti-HIV. The recent success of pyrazole COX-2 inhibitor has further highlighted the importance of these heterocycles in medicinal chemistry. Methodology: The steps included condensation followed by cyclization or MCR, either in a step-wise manner or in one pot has been achieved successfully to obtain this class of heterocycles under different conditions. Phosphorus ox.. Read More»
  DOI: 10.4172/2155-9619.1000250

  Abstract PDF