Cancer Science & Therapy

Ayman G Ghobrial

Publications

• Research Article
  CD44 and CD44 Variant 6 in Children with Acute Lymphoblastic Leukemia
  Author(s): Ahmad A Omran, Esmat A Elsharkawy, Ayman G Ghobrial, Hosny B Hamed, Waleed M Abd el Hameed, Nagwa I Okaily and Abdel-Azeem M. El-MarazyAhmad A Omran, Esmat A Elsharkawy, Ayman G Ghobrial, Hosny B Hamed, Waleed M Abd el Hameed, Nagwa I Okaily and Abdel-Azeem M. El-Marazy
  
  Background and objectives: Acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid progenitor cells. Many prognostic factors are important for therapeutic assignment. The cell adhesion molecule CD44 is involved in pathologic activities of tumour cells and hematological malignancies. CD44v6 is an important isoform of CD44 family. It plays an important role in the growth and metastasis development in some hematological malignancies The aim of this study is to detect CD44 and CD44v6 expression in children with acute lymphoblastic leukemia and to correlate them with prognosis and other standard prognostic factors for ALL. Subjects and methods: The study carried out on 57 children divided into: group Ӏ included 40 newly diagnosed children with acute lymphoblastic leukemia who were followed up for one year and.. Read More»
  DOI: 10.4172/1948-5956.1000377

  Abstract PDF