Egypt
Research Article
Association of Angiotensin Converting Enzyme Gene Polymorphism and Possible High Risk Factors with Essential Arterial Hypertension in Egyptian Patients
Author(s): Eman R. Abdel-hamid, Eman A. Mohammed, Azza Z. Aleraky and Fouad M. BadrEman R. Abdel-hamid, Eman A. Mohammed, Azza Z. Aleraky and Fouad M. Badr
Background: Hypertension (HT) is a public health challenge due to its high prevalence, and being a major risk factor for cardiovascular diseases. HT is a multifactorial disorder with genetic and environmental interactive factors.
Aim: This study aims to evaluate association of angiotensin converting enzyme gene polymorphism (I/D) with blood pressure among Egyptian patients with essential hypertension and the interrelationship with other clinical parameters.
Subjects and methods: Eighty four patients with essential hypertension were included in this cross sectional descriptive study. Venous blood samples were withdrawn for DNA extraction, determination of different genotypes of ACE gene (I/D) polymorphism by polymerase chain reaction (PCR) and measuring serum ACE levels, lipid profile, blood sugar and creatinin.
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DOI:
10.4172/2168-9547.1000165
Molecular Biology: Open Access received 607 citations as per Google Scholar report