Journal of AIDS & Clinical Research

B Ryan Phelps

Publications

• Commentary
  Long-Acting, Injectable Antiretroviral Therapy for the Management of HIV Infection: An Update on a Potential Game-Changer
  Author(s): Linda Mobula, Matt Barnhart, Christine Malati, Natella Rakhmanina, Tom Minior, Anouk Amzel, Robert Ferris and B Ryan PhelpsLinda Mobula, Matt Barnhart, Christine Malati, Natella Rakhmanina, Tom Minior, Anouk Amzel, Robert Ferris and B Ryan Phelps
  
  The efficacy of daily oral antiretroviral (ARVs), even when combined with supplemental adherence strategies, remains limited by non-adherence. Resistance and treatment failure resulting from missed ARV doses continue to hamper efforts to curb the epidemic. This commentary argues that we must simplify ARV regimens even further, and highlights the potential for long-acting injectable (LAI) formulations to facilitate weekly, monthly, and multi-month ARV regimens in both resource rich and resource poor settings. We summarize the latest progress in LAI development and reflect on the potential of LAIs to revolutionize HIV management and define the next frontier of HIV medicine. .. Read More»
  DOI: 10.4172/2155-6113.1000466

  Abstract PDF