Medicinal Chemistry

Bangyuan Wu

Publications

• Research Article
  Effect of Vanadium on TLR4 and TLR7 mRNA Expression in the Lymphoid Organs of Broilers
  Author(s): Wei Cui, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Xiaodong Liu and Bangyuan WuWei Cui, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Xiaodong Liu and Bangyuan Wu
  
  TLRs are important innate immune receptors. It has been found that vanadium can affect the immune function in broilers. However, vanadium action in the regulation of TLRs is unknown. A total of 420 one-day-old avian broilers were divided into six groups, and fed on a corn-soybean basal diet as control diet (vanadium 0.073 mg/kg) or the same diet supplemented with vanadium at the doses of 5, 15, 30, 45 and 60 mg/kg in the form of ammonium metavanadate. TLR4 and TLR7 mRNA expression in lymphoid organs of each group were studied by real time RT-PCR form. The results indicated that the TLR4 and TLR7 mRNA expression in thymus and TLR4 mRNA expression in bursa were down-regulated in the 60 mg/kg group. The TLR7 mRNA expression in bursa was down-regulated in 30 mg/kg, 45 mg/kg and 60 mg/kg groups, and up-regulated in the 5 mg/kg group. Also, the TLR4 and TLR.. Read More»
  DOI: 10.4172/2161-0444.1000123

  Abstract PDF