Journal of Blood & Lymph

Barbara Giannetti

Publications

• Research Article
  Cytokines Behavior in Multiple Myeloma Patients during Zoledronic Acid Treatment
  Author(s): Ombretta Annibali, Maria Teresa Petrucci, Maria Cristina Tirindelli, Barbara Giannetti, Bruno Vincenzi, Daniele Santini, Chiara Sarlo, Valeria Tomarchio, Robin Foa and Giuseppe AvvisatiOmbretta Annibali, Maria Teresa Petrucci, Maria Cristina Tirindelli, Barbara Giannetti, Bruno Vincenzi, Daniele Santini, Chiara Sarlo, Valeria Tomarchio, Robin Foa and Giuseppe Avvisati
  
  Objective: Multiple Myeloma (MM) is characterized by uncoupling of bone resorption from bone formation which leads to the predominance of resorption. Bisphosphonates are chemical compounds that selectively concentrate at the interface of the active osteoclasts and the bone resorption surface where they inhibit osteoclast activity. Aim of this study was to describe cytokines behaviour in MM and to evaluate whether zoledronic acid could have an in vivo anti-angiogenic property in MM as observed in solid tumours.Methods: Serum samples from 29 (16 males and 13 females) consecutive MM patients with lytic bone lesions treated with 4 mg of zoledronic acid were tested for platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), tumor necrosis factor (TNF α) and insulin growth factor (IGF-I). Basal cyto.. Read More»
  DOI: 10.4172/2165-7831.1000184

  Abstract PDF