Journal of Tissue Science and Engineering

Beer GM

Publications

• Research Article
  Adipose Derived Tissue Engineered Heart Valve
  Author(s): Frese L, Sanders B, Beer GM, Weber B, Driessen-Mol A, Baaijens FPT and Hoerstrup SPFrese L, Sanders B, Beer GM, Weber B, Driessen-Mol A, Baaijens FPT and Hoerstrup SP
  
  Abstract Introduction: A major challenge associated with heart valve tissue engineering is the in vitro creation of mature tissue structures compliant with native valve functionality. Various cell types have been investigated for heart valve tissue engineering. In addition to prenatal, umbilical cord- and vascular-derived cells, mesenchymal stem cells (MSCs) have gained large interest for tissue engineering purposes, because of their broad differentiation potential. However, bone marrow derived MSCs require a highly invasive harvesting procedure and decline in both cell number and differentiation potential proportionally with the donor’s age. In contrast, adipose derived stem cells (ADSCs) represent an interesting alternative. The ease of repeated access to subcutaneous adipose tissue as well as the less invasive donation procedures provide clear advantages. Therefore, this stud.. Read More»
  DOI: 10.4172/2157-7552.1000156

  Abstract PDF