Journal of Nephrology & Therapeutics

Beiro I

Publications

• Research Article
  Urinary Biomarkers for Kidney Disease in ATTR Amyloidosis
  Author(s): Ana Rocha, Bravo F, Beiro I, Vizcano J, Oliveira JC and Lobato LAna Rocha, Bravo F, Beiro I, Vizcano J, Oliveira JC and Lobato L
  
  Aim: The detection and prognosis of nephropathy in transthyretin amyloidosis depends on albuminuria and renal function. Knowing that urinary levels of alpha-1 microglobulin and beta-2 microglobulin reflect tubular dysfunction while urinary alpha-2 macroglobulin implies glomerular damage, we decide investigate the diagnostic value of these markers in the patients with transthyretin amyloidosis. Methods: Serum and urinary samples collected from 30 patients and 11 asymptomatic carriers were tested for alpha-1 microglobulin, beta-2 microglobulin, alpha-2 macroglobulin, albumin, creatinine and cystatin C. Results: Pathological urinary alpha-1 microglobulin was detected in 17 patients, beta-2 microglobulin in 6 and alpha-2 macroglobulin in 5; 5 patients had albuminuria (mg/g creatinine) 30-300 and in 20 patients values >300 were present. Asymptomatic carriers.. Read More»
  DOI: 10.4172/2161-0959.1000181

  Abstract PDF