Directorate of Traditional and Modern Medicine Research, Ethiopian Public Health Institute,
PO Box 1242, Addis Ababa
Ethiopia
Research Article
Evaluation of Diuretic Activity of Different Solvent Fractions of Methanol Extract of Carissa edulis Root Bark in Rats
Author(s): Selamu Kebamo, Eyasu Makonnen, Asfaw Debella and Bekesho GeletSelamu Kebamo, Eyasu Makonnen, Asfaw Debella and Bekesho Gelet
Background: Carissa edulis is used traditionally for the treatment of HIV/AIDS symptoms, rheumatism, gonorrhea, syphilis, rabies, malaria, epilepsy, chronic joint pain, and as a diuretic.
Objective: The present study investigates the diuretic activity of different solvent fractions of 80% methanol Soxhlet extract of Carissa edulis root bark in normal wistar rats.
Materials and methods: The volumes of urine output and urinary electrolyte were the parameters determined by oral administration of single doses of different solvent fractions of 80% methanol Soxhlet extract of Carissa edulis root bark at three dose levels (50, 500 and 1000 mg/kg) in normal wistar rats.
Results: The petroleum ether and n-butanol fractions showed no significant effect on the urine.. Read More»
DOI:
10.4172/2161-0444.1000304
Medicinal Chemistry received 6627 citations as per Google Scholar report
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