Pulmonary & Respiratory Medicine

Benito Yard

Publications

• Research Article
  Therapeutic Effects of Bone Marrow-derived Progenitor Cells in Lipopolysaccharide-induced Acute Respiratory Distress Syndrome
  Author(s): Neysan Rafat, Gregor Kowanetz, Jörg Krebs, Charalambos Tsagogiorgas, Christian Betzen, Verena Ghezel-Ahmadi, Benito Yard, Grietje Beck and Christine DachoNeysan Rafat, Gregor Kowanetz, Jörg Krebs, Charalambos Tsagogiorgas, Christian Betzen, Verena Ghezel-Ahmadi, Benito Yard, Grietje Beck and Christine Dacho
  
  Objective: Endotoxin-induced acute respiratory distress syndrome (ARDS) is characterized by diffuse dysfunction of the microvasculature including increased permeability with oedema formation and apoptosis or necrosis of endothelial- and epithelial cells. Concomitantly, an increased concentration of circulating endothelial progenitor cells (EPC) was found in septic patients, which seem to be involved in pulmonary regeneration. The number of circulating EPC correlated inversely to disease severity and mortality. Since bone marrow-derived endothelial progenitor cells (BMDPC) were found homing to damaged lung tissue, a reparative process seems to be initiated right after the initiation of vessel damage or degeneration. In the present study we investigated the potential of BMDPC as a treatment strategy in lipopolysaccharide (LPS)-induced ARDS. Methods:.. Read More»
  DOI: 10.4172/2161-105X.1000174

  Abstract PDF