Chemical Sciences Journal

Bhuva RG

Publications

• Research Article
  Design, Synthesis and Comparative Study of Anti-Microbial Activities on Barbituric Acid and Thiobarbituric Acid based Chalcone Derivatives Bearing the Pyrimidine Nucleus
  Author(s): Dhorajiya BD, Bhuva RG and Dholakiya BZDhorajiya BD, Bhuva RG and Dholakiya BZ
  
  A new comparative series of barbituric acid and thiobarbituric acid based chalcone derivatives bearing the pyrimidine nucleus were synthesized. The chemical structures of the resulting molecules were characterised by means of FT-IR (Fourier Transform Infrared) 1H NMR, 13C-NMR (Nuclear Magnetic Resonance) and HMBC (Heteronuclear Multiple-Bond Correlation) and Elemental Analysis. All synthesized compounds were subjected to in vitro antimicrobial screening against four bacterial strains i.e., one Gram Positive (Bacillus subtilis MTCC 441), two Gram Negative (E. coli MTCC 443, P. aeruginosa MTCC 1688), and one Fungal (C. albicans MTCC 227) Strains. The structure activity relationship is discussed on the basis of bioactivity results, various functional groups present and position of the functional group at various positions of the synthesi.. Read More»
  

  Abstract PDF