Journal of Bioanalysis & Biomedicine

Birendra Kumar Roy

Publications

• Research Article
  Effect of Induced Mastitis on Disposition Kinetics of Gatifloxacin Following Intravenous Administration in Goats
  Author(s): Vishakha Singh, Mahendra Ram, Birendra Kumar Roy and Kaushal Kumar SinghVishakha Singh, Mahendra Ram, Birendra Kumar Roy and Kaushal Kumar Singh
  
  Disposition kinetic studies of gatifl oxacin (GAT) was conducted after single i.v. dose (10 mg/kg) in six healthy and six mastitic Black Bengal lactating goats. Mastitis was induced by coagulase positive S. aureus. The concentration of the drug was estimated by HPLC. The maximum milk concentration was found to be signifi cantly (p< 0.05) higher in mastitic goats (12.78 ± 3.11 μg/ml) than healthy (9.17 ± 1.41 μg/ml). The therapeutic milk concentration in mastitic goats (0.13 ± 0.05 to 12.41 ± 2.99 μg/ml) was maintained for 48 h which was signifi cantly (p<0.01) longer than in healthy goats (24 h). The elimination half-life in plasma and milk of mastitic goats (5.82 ± 0.67 and 8.20±0.21 h) was signifi cantly (p<0.01) higher than healthy (4.54 ± 0.75 and 3.67±0.09 h).It indicates that GAT persisted in the body of ma.. Read More»
  DOI: 10.4172/1948-593X.1000020

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