Journal of Tissue Science and Engineering

Blackstone BN

Publications

• Research Article
  Structural Alterations in Scaffold Architecture in Response to Mechanical Stimuli
  Author(s): Blackstone BN, Wolever JD and Powell HMBlackstone BN, Wolever JD and Powell HM
  
  Background: Though mechanical stimulation has been shown to improve mechanical properties of many engineered tissues, little is known about the impact of stimulation on scaffold architecture. In engineered tissues where the scaffold comprises a large portion of the tissue, mechanical signals are transferred from the external environment through the scaffold to the cells. Thus, a greater understanding of the architectural changes a scaffold experiences during mechanical stimulation may provide new knowledge on the communication between the cells and scaffold, during dynamic in vitro tissue development. Methods: Two distinct scaffold architectures were fabricated via lyophilization or electro-spinning of collagen. Pore size of lyophilized scaffolds, fiber diameter and inter-fiber distance of electrospun scaffolds, and ultimate tensile strength, linear s.. Read More»
  DOI: 10.4172/2157-7552.1000122

  Abstract PDF