Journal of AIDS & Clinical Research

Blake Max

Publications

• Research Article
  Renal Function Recovery and HIV Viral Suppression Following Tenofovir Discontinuation for Renal Impairment
  Author(s): Francine Touzard Romo, Mariam Aziz, Britt Livak, Emily Huesgen, Ben Colton, Timothy P. Flanigan, Blake Max and Harold KesslerFrancine Touzard Romo, Mariam Aziz, Britt Livak, Emily Huesgen, Ben Colton, Timothy P. Flanigan, Blake Max and Harold Kessler
  
  Background: Tenofovir associated nephrotoxicity (TDFN) is well recognized. This study describes the trend of renal function recovery and virologic consequences after cessation of tenofovir (TDF) for suspected TDFN. Methods: This was a retrospective chart review of 241 patients who underwent HLA-B*5701 allele testing between January 2007-December 2010. Demographics and clinical characteristics were compared at baseline, 3, 6, and 12 month between patients that continued and discontinued TDF. Factors associated with renal function recovery were assessed by multivariable logistic regression. Results: Eighty patients were identified with TDFN; 84% male, 74% African American (AA) with a median age of 55 years, and median length of TDF use for 122 weeks. Renal recovery at 12 months differed in those who stopped versus (vs.) continued TDF (83% vs. 57% p=0.03). In a crude analysis, baseline c.. Read More»
  DOI: 10.4172/2155-6113.1000379

  Abstract PDF