International Journal of Neurorehabilitation

Brenda Sedlnitzky-Semler

Publications

• Research Article
  Normal Pressure Hydrocephalus, Dementia and Kynurenic Acid
  Author(s): Berthold Kepplinger, Jochen Reuss, Brenda Sedlnitzky-Semler, Roman Sobota, Pavol Kalina and Halina BaranBerthold Kepplinger, Jochen Reuss, Brenda Sedlnitzky-Semler, Roman Sobota, Pavol Kalina and Halina Baran
  
  A female 49 years old patient with vestibular schwannoma developed normal pressure hydrocephalus. Patient complained about gait disturbance, urinary incontinence and memory impairment. Investigation of clinical parameter and measurement of kynurenic acid in the cerebrospinal fluid (CSF) and serum in patients with normal pressure hydrocephalus and in corresponding controls (CO; N=15) were performed. Within investigated parameters significant increase of protein and IgG levels in CSF were found in patient with normal pressure hydrocephalus. Furthermore, kynurenic acid was increased in the CSF by 60% and in the serum by 40%, comparing to CO subjects. Kynurenic acid level in CO was in the CSF and serum 2.77 ± 0.23 and 53.4 ± 4.0 nM, respectively. Three lumbar punctures were applied to patient with normal pressure hydrocephalus and clinical parameters partial.. Read More»
  DOI: 10.4172/2376-0281.1000269

  Abstract PDF