Germany
Research Article
Therapeutic Decisions Often Cannot be Maintained for One Year in Crohn's Disease Patients
Author(s): Lamprecht G, Reichel C, Heitmann L, Li Y, Brinkmann B, Holle A, Schäffler H, Huth A, Hauenstein K and Klar GLamprecht G, Reichel C, Heitmann L, Li Y, Brinkmann B, Holle A, Schäffler H, Huth A, Hauenstein K and Klar G
Objective: In Crohn's disease (CD) major therapeutic decisions are triggered by failure of medical therapy or by a flare and are based on various diagnostic modalities, the prior clinical course and the patient’s perception. We analyzed, whether under real world conditions a therapeutic decision can be maintained over 12 months or needs to be adjusted in this time.
Methods: In 50 patients diffusion-weighted magnetic resonance imaging (DW MRI) studies were used as an indicator for the need to make a therapeutic decision. Decisions were based on the prior clinical course, endoscopy, ultrasound, DW MRI and the patient’s perception of the situation and were categorized as surgery (A), no change (B) or intensification of medical therapy (C). The clinical course was analyzed using CDAI and CRP at 3, 6 and 12 months follow up.
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