Journal of Cytology & Histology

Bruno Flamion

Publications

• Research Article
  CD44-Positive Cells and Hyaluronan are a Hallmark of a Rat Model of Aristolochic Acid Nephropathy
  Author(s): Anne-Emilie Decleves, Agnieszka Pozdzik, T Baudoux, Isabelle Habsch, Eric De Prez, Bruno Flamion, Joelle Nortier and Nathalie CaronAnne-Emilie Decleves, Agnieszka Pozdzik, T Baudoux, Isabelle Habsch, Eric De Prez, Bruno Flamion, Joelle Nortier and Nathalie Caron
  
  Background: Aristolochic acid (AA) Nephropathy (AAN) is characterized by tubulointerstitial injury leading to fibrosis and tubular atrophy. Defective regeneration of tubular cells was hypothesized as a mechanism leading to Proximal Tubular Epithelial Cell (PTEC) atrophy. Here, we examined the distribution of CD44, an adhesion molecule involved in differentiation, and its main ligand, Hyaluronan (HA), in an experimental AAN model. Methods: Wistar rats were injected daily with AA or vehicle during 35 days. Tubular enzymuria and tissue expression of CD44 and HA were evaluated at days 3, 7, 10, 21 and 35. Co-expressions of CD44 and PCNA (proliferation), vimentin (mesenchymal phenotype), a-SMA (myofibroblasts), and CD133 (progenitor cells) were investigated. Results: AA induced acute tubular damage followed by PTEC atrophy. In controls, CD44 was limited to t.. Read More»
  DOI: 10.4172/2157-7099.1000186

  Abstract PDF