Italy
Research Article
Genetic Insights from a Molecular Pathway Analysis on Two Independent Samples of Autistic Patients
Author(s): Drago A, Calabro M, Crisafulli C and Rasmussen SKDrago A, Calabro M, Crisafulli C and Rasmussen SK
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by limited interest and lacking ability in social interactions, repetitive behavior and dysfunction in social communication. ASD runs in families. Twin studies suggest a strong genetic basis for ASD. The complete definition of a genetic profile at risk for ASD is nevertheless currently lacking.
Methods: NIHM-Autism datasets 3 and 4 (n=1233 and n=2890 respectively) were analyzed. A molecular pathway analysis was conducted. Quality analysis was run as usual (λ values). Plink and R (ReactomePA and Bioconductor packages) served for TDT, association tests and the molecular pathway analysis.
Results and Discussion: The “Adherens junctions’ interactions pathway” and “Axon guidance” were enriched in the .. Read More»
DOI:
10.4172/1747-0862.1000326
Molecular and Genetic Medicine received 3919 citations as per Google Scholar report