Journal of Cytology & Histology

Carlson Jennifer

Publications

• Research Article
  Wnt-ß-Catenin Pathway Regulates Vascular Mimicry in Triple Negative Breast Cancer
  Author(s): De Pradip, Carlson Jennifer, Leyland-Jones Brian and Dey NandiniDe Pradip, Carlson Jennifer, Leyland-Jones Brian and Dey Nandini
  
  The Wnt-beta-catenin pathway (WP) regulates different aspects of cell fate, migration and polarity. Inappropriate deregulation of this pathway leads to oncogenic and metastatic changes. The Triple Negative (TN) subset of BC (the absence of hormone receptors and absence of amplification/overexpression of HER2 receptors) exhibits aggressive clinical behavior and has poor clinical outcome. We have recently identified WP as one of the key signature pathways in TNBC associated with metastasis [1,2]. Here we report for the first time that WP controls metastasis-associated phenotype of Vascular Mimicry (VM) in TNBC. We have established 2D and 3D models to study VM in this subset of BC and characterized different TNBC cell lines in terms of VM and identified the role of WP in the regulation of VM. To establish the role of WP in the regulation of VM in TNBC, we have used (1) a pharmacological .. Read More»
  DOI: 10.4172/2157-7099.1000198

  Abstract PDF