Molecular Biomarkers & Diagnosis

Carolina Duarte

Publications

• Research Article
  Identification of Circulating Natural Antibodies against Endogenous Mediators in the Peripheral Blood Sera of Patients with Osteoarthritis of the Knee: A New Diagnostic Frontier
  Author(s): Yulia A Savitskaya, Carolina Duarte, Norma Marín, René Téllez, Alfonso Alfaro and Clemente IbarraYulia A Savitskaya, Carolina Duarte, Norma Marín, René Téllez, Alfonso Alfaro and Clemente Ibarra
  
  Introduction: The presence of NA against EM regarding specificity and have gained increasing attention in proteome analysis for diagnosis, developing, monitoring and effective treatment of osteoarthritis of the knee (kOA). An understanding of the various regulatory systems controlling blood vessel growth, inflammation and pain in the join should lead to help explain kOA disease progression. To investigate the specific presence of NA (IgM, IgG, IgA) against EM (BK, AII, VEGF, bFGF) in the sera of kOA patients and control and to correlate this with process of joint destruction. Methods: In this study novel immunoconjugates were designed, synthesized and then used to develop a rapid, specific and sensitive ELISA method to directly detect immune complexes (NA-EM) in humans. Following this procedure, we examined variations in the levels of natural .. Read More»
  DOI: 10.4172/2155-9929.1000135

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