School of Medicine of Ribeirao Preto/USP,
Av. Bandeirantes 3900, Campus Universitário, Ribeirao Preto, SP 14049-900
Brazil
Research Article
Effect of Coadministration of Etonogestrel Implant and Antiretroviral
Therapies Containing Efavirenz or Lopinavir/Ritonavir on the Metabolism
of Women Living with HIV/AIDS
Author(s): Tatiana R Rocha Prandini, Maria Valeria Bahamondes, Milena B Brito, Eliana Amaral, Luis Bahamondes, Geraldo Duarte, Silvana M Quintana, Rui A Ferriani and Carolina Sales VieiraTatiana R Rocha Prandini, Maria Valeria Bahamondes, Milena B Brito, Eliana Amaral, Luis Bahamondes, Geraldo Duarte, Silvana M Quintana, Rui A Ferriani and Carolina Sales Vieira
Background: Concomitant use of antiretroviral therapy (ART) and hormonal contraceptives should be safe for women while maintaining medication efficacy without causing significant immunological or metabolic changes. However, the metabolic effect of the concomitant use of etonogestrel (ENG)-releasing implant and commonly used ARTs is not known. Objective: To evaluate the effect of coadministration of ENG-releasing implant and ARTs containing lopinavir/ ritonavir or efavirenz on the metabolic parameters of women living with human immunodeficiency virus (HIV) infection/ acquired immune deficiency syndrome (AIDS). Methods: This is an open, prospective, non-randomized exploratory study. Forty-five women who sought to receive the ENG contraceptive implant were selected, including 15 non-ART users, 15 zidovudine/lamivudine (AZT/3TC)+lopinavir/ritonavir users and 15 AZT/3TC+efavirenz users f.. Read More»
DOI:
10.4172/2155-6113.1000674
Journal of AIDS & Clinical Research received 5264 citations as per Google Scholar report