Institute of Biology,
Coyoacan
Mexico
Research Article
Free and DNA Adducted Aflatoxins in Chronic Liver Diseases that Predispose Patients to Hepatocellular Carcinoma in Mexico
Author(s): Alvarez-Banuelos MT, Carvajal-Moreno M, Mendez-Ramirez I and Rojo-Callejas FAlvarez-Banuelos MT, Carvajal-Moreno M, Mendez-Ramirez I and Rojo-Callejas F
Aflatoxins are mutagenic hepatocarcinogenic fungal metabolites that contribute to chronic hepatitis B and C and viral cirrhosis, which can both evolve into hepatocellular carcinoma.
Objective: To identify and quantify free aflatoxins and AFB1-N7-guanine (AFB1-N7-Gua) adducts (active carcinogen) in the urine of Mexican patients with chronic liver diseases.
Methods: Urine samples from 210 Mexican patients with chronic liver diseases, hepatitis B or C, or viral cirrhosis and four control groups: 1) patients with alcoholic cirrhosis, 2) patients with no hepatic diseases, 3) patients with kidney failure, and 4) healthy persons, were analyzed for free aflatoxins and AFB1-N7-Gua adducts by Inhibitory Indirect ELISA and high performance liquid chromatography, and both methods produced similar results (R2=0.90). A questionnaire regarding foods .. Read More»
DOI:
10.4172/1948-5956.1000363
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