Journal of Cytology & Histology

Château-Joubert S

Publications

• Research Article
  Changes in Pancreatic Islet Mass in Grey Mouse Lemurs (Microcebus murinus) Submitted to Caloric Restriction or Resveratrol Administration
  Author(s): Hurion M, Château-Joubert S, Servely JL, Pifferi F, Boyer C, Perret M, Djelti F, Aujard F and Cordonnier NHurion M, Château-Joubert S, Servely JL, Pifferi F, Boyer C, Perret M, Djelti F, Aujard F and Cordonnier N
  
  Caloric restriction and resveratrol intake have beneficial effects on health, especially in the prevention and improvement of diabetes. Based on this evidence, this study has been conducted in order to examine the normal architecture of pancreatic islets and the long term effects on endocrine pancreas of standard diet, caloric restriction, or resveratrol in 19 adult grey mouse lemurs. Immunohistochemistry, with anti-insulin and anti-glucagon antibodies, and morphometric analysis were performed. The normal pancreatic islet was composed of an outer circle of α cells and a large inner body of β cells, the percentages of each cell types being 10.3 ± 3.3% and 69.7 ± 1.8%, respectively. A marked increase of the pancreatic islet mass was detected in 6 animals: 2 animals under standard diet,1 animal under calorie restricted diet, and 3 animals under standard diet supp.. Read More»
  DOI: 10.4172/2157-7099.1000439

  Abstract PDF