Palestine
Research Article
Determination of Carteolol in Pure and Pharmaceutical Formulation by
Spectrophotometric Method
Author(s): Malek Okdeh, Chahid Moustpha and Mohammad ShraitahMalek Okdeh, Chahid Moustpha and Mohammad Shraitah
An accurate, simple, fast, and good sensitive Spectrophotometric method have been developed for the determination of Carteolol based on the formation of complex (ion-pair complexes) between the Carteolol (CRT) and Alizarin yellow R Sodium salt (AR) at pH=11.20. This reaction produces a complex red color which is absorbed maximally at 500 nm. Beer’s law was obeyed in the range of 1.80-197.30 ug/mL with molar absorptivity of 1.7663×103 L mole-1cm-1. The effects of analytical parameters on the reported system were investigated. The results were validated statistically. The proposed method was applied to commercially available tablets. Interferences of the other ingredients and excipients were not observed.
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DOI:
10.4172/2161-0444.1000334
Medicinal Chemistry received 6627 citations as per Google Scholar report