Journal of Clinical & Medical Genomics

Chaitra KL

Publications

• Research Article
  Variants of PGIS and PPARγ in Idiopathic Pulmonary Arterial Hypertension
  Author(s): Shivani Vadapalli, Chaitra KL, Satyanarayana ML, Surekha Rani H, Sastry BKS and Pratibha NallariShivani Vadapalli, Chaitra KL, Satyanarayana ML, Surekha Rani H, Sastry BKS and Pratibha Nallari
  
  Introduction: Idiopathic Pulmonary Arterial Hypertension (IPAH) is a subset of a heterogeneous group of diseases called Pulmonary Arterial Hypertension (PAH), characterized by elevated pulmonary arterial pressure (PAP) and is associated with severe arteriopathy, vascular lesions, and right heart failure. The role of prostacyclin synthase, an enzyme responsible for production of prostacyclin, and peroxisome proliferator-activated receptor gamma, involved in many cellular activities, is studied here. Objectives: The objective of the study is to determine any association of prostacyclin synthase and Peroxisome proliferator-activated receptor gamma with Idiopathic Pulmonary Arterial Hypertension Materials and methods: A total of 77 IPAH patients and 100 controls were genotyped using PCR SSCP and RFLP, and appropriate s.. Read More»
  DOI: 10.4172/2472-128X.1000130

  Abstract PDF