Pharmaceutical Regulatory Affairs: Open Access

Chakraborty AK

Publications

• Review Article
  Conceptual Drug Discovery and Societal Status may not be Sufficient to Combat Multidrug-Resistant Infections
  Author(s): Chakraborty AKChakraborty AK
  
  The period between the 1940s and 1960s is commonly referred to as “the golden era of antibiotic discovery” saving million’s life and good health. However, generation and spread of multi-drug resistant bacteria are highly claiming life. MDR, XDR and PDR infections are alarming as cautioned by CDC and WHO with ten million infections worldwide. ESBL and MBL beta-lactamases (blaOXA, blaNDM1), heterogeneous acetyl/phospho/adenyl-transferases (catB3, aacC1, strA/B, aphA4, ANT) and drug efflux proteins (MFS/RND/ABC) are very much abundant in plasmids and chromosomes of most Enterobacteriaceae infections. This has happened due to three main reasons: First, mdr genes are assembled into large conjugative plasmids allowing to transfer of mdr genes into household bacteria by conjugation and secondly, drug industries are reluctant to invest in new drug discovery.. Read More»
  

  Abstract PDF