Molecular Biomarkers & Diagnosis

Chalupova L

Publications

• Research Article
  CTRP1: A Molecular Link between Obesity and Hypertension
  Author(s): Chalupova L, Halupova L, Zakovska A, Krejci G and Stejskal DChalupova L, Halupova L, Zakovska A, Krejci G and Stejskal D
  
  Background: CTRP1, a recently identified adipokine, was found to stimulate aldosterone production. Serum CTRP1 and plasma Aldosterone levels were significantly increased in patients with diabetes mellitus and metabolic syndrome. Therefore, it would be interesting to investigate whether the secretion of CTRP1 in human serum is associated with hypertension as well as with diabetes mellitus. Aim: This study evaluated serum CTRP1 and aldosterone concentrations in healthy individuals and in patients with diabetic nephropathy. Methods: Serum samples from 32 healthy individuals and 44 patients with diabetic nephropathy were measured for CTRP1, Aldosterone, diabetes-related biomarkers and renal disease-related biomarkers by enzyme-linked immunosorbent assay (ELISA). Results: Correlation analyses showed.. Read More»
  DOI: 10.4172/2155-9929.1000289

  Abstract PDF