Environmental & Analytical Toxicology

Changbhale S.S

Publications

• Research Article
  An Immunoinformatics Approach to Design Synthetic Peptide Vaccine from Dendroaspis polylepis polylepis Dendrotoxin-K(DTX-K)
  Author(s): Changbhale S.S, Chitlange N.R, Gomase V.S and Kale K.VChangbhale S.S, Chitlange N.R, Gomase V.S and Kale K.V
  
  Dendroaspis polylepis polylepis is the most toxic snake commonly known as black mamba, the black mamba venom contains Dendrotoxin-K which is highly specific and virulently toxic protein. Antigenic peptides of Dendrotoxin toxic protein are most suitable for peptide vaccine development because with single epitope, the immune response can be generated in large population. Analysis shows MHC class II binding peptides of antigenic protein from Dendroaspis polylepis polylepis DTX-K are important determinant for protection against several venom toxins. In this assay we predicted the binding affinity of Dendroaspis polylepis polylepis DTX-K protein having 79 amino acids, which shows71nonamers. In this analysis, we found the High affinity TAP Transporter peptide regions as, 37-KRKIPSFYY(score-9.550), 45-YKWKAKQCL (Score-8.581) 36-CKRKIPSFY (Score-7.685), 24-AKYCKLPLR (Score-7.669), 42-SFYYKWKA.. Read More»
  DOI: 10.4172/2161-0525.1000157

  Abstract PDF