GET THE APP

..

Molecular Biomarkers & Diagnosis

ISSN: 2155-9929

Open Access

Chantal Vidal


Tanzania

Publications
  • Short Communication
    Elevated Mitochondrial and Heme Function as Hallmarks for Non-Small Cell Lung Cancers
    Author(s): Chantal Vidal, Sagar Sohoni and Li ZhangChantal Vidal, Sagar Sohoni and Li Zhang

    Many targeted therapies have been developed to treat lung cancer. Unfortunately, however statistical data over the past two decades suggest only a slight improvement in a patient's survival rate after diagnosis. Clonal evolution and tumor heterogeneity are the major obstacles in designing effective targeted treatments against cancer. To create more comprehensive treatments, emerging therapies target bioenergetic pathways of cancer cells. Like normal cells, cancer cells can generate energy only through glycolysis and oxidative phosphorylation. Notably, a number of studies have shown that many types of cancer cells rely heavily on mitochondrial respiration. Importantly, research carried out in the authors’ laboratory showed that non-small cell lung cancer cells exhibit increased levels of mitochondrial and heme function. Hence, limiting heme availability interferes with bioene.. Read More»
    DOI: 10.4172/2155-9929.1000305

    Abstract PDF

Relevant Topics

Google Scholar citation report
Citations: 2054

Molecular Biomarkers & Diagnosis received 2054 citations as per Google Scholar report

Molecular Biomarkers & Diagnosis peer review process verified at publons

Indexed In

 
arrow_upward arrow_upward