Journal of AIDS & Clinical Research

Charlotte Sakarovitch

Publications

• Research Article
  Real Life HAART Efficacy in Chronically HIV-1 Infected Children 15-Year Follow-Up
  Author(s): Fabrice Monpoux, Amandine Rubio, Charlotte Sakarovitch, Eric Fontas, Jacqueline Cottalorda-Dufayard and Christian PradierFabrice Monpoux, Amandine Rubio, Charlotte Sakarovitch, Eric Fontas, Jacqueline Cottalorda-Dufayard and Christian Pradier
  
  Background: It is now widely accepted that the antiretroviral first line-treatment basis in HIV-1 infected children is a combination of 2 nucleoside reverse transcriptase inhibitors and 1 protease inhibitor or 1 non NRTI. However, after few months or years, some patients presented with virological failure. Objective: Using a “real life conditions” cohort, we aimed to study the median duration of Viral Controlled Replication (VCR) and the factors associated with failure in infected children. Methods: Thirty six HIV-1 infected patients were followed between September 1996 and September 2010. Children were included starting from the date of initiation of their first successful HAART. Duration of effective VCR was defined as a length, in months, from inclusion to virological failure defined as a HIV-1 PCR-RNA higher than 400 c/ml. Results: The overall median VCR duration was 4.. Read More»
  DOI: 10.4172/2155-6113.1000178

  Abstract PDF