Pulmonary & Respiratory Medicine

Charlotte Suppli Ulrik

Publications

• Review Article
  Non-antibiotic Inhaled Agents for Stable Non-CF Bronchiectasis in Adults - A Systematic Review
  Author(s): Katrine Fjaellegaard, Melda Dönmez Sin, Andrea Browatzki and Charlotte Suppli UlrikKatrine Fjaellegaard, Melda Dönmez Sin, Andrea Browatzki and Charlotte Suppli Ulrik
  
  Aim: Update on efficacy and safety of non-antibiotic therapy for stable non-cystic fibrosis (CF) bronchiectasis. Methods: Systematic review based on the PRISMA-guidelines. Results: Fifteen studies (1278 patients) fulfilled the inclusion criteria. Studies (n = 3) suggest that inhaled hypertonic saline may be beneficial in patients with non-CF BE, although possibly not superior to isotonic saline. The effect of hypertonic saline on QoL, lung function, and exacerbation rate has, at best, been inconsistent. Inhaled mannitol (n = 6) affects sputum characteristics, but with no significant effect on exacerbation rate, lung function, or sputum, although it may have an effect on QoL and time to first exacerbation. High-dose inhaled corticosteroids (ICS) (n = 4) reduce sputum volume and eosinophils, possibly due to concomitant asthma, but with no effect on s.. Read More»
  DOI: 10.4172/2161-105X.1000337

  Abstract PDF