Cardiovascular Diseases & Diagnosis

Chen Hao

Publications

• Research Article
  Development and Comparison of a Warfarin-Dosing Algorithm in Chinese Han Patients with Atrial Fibrillation
  Author(s): Chen Hao, Tong Jia-bin, LÜ You, Chong Jia, Tian Wei-meng, LI Peng, DU Xin, MA Chang-sheng and Yang Jie-fuChen Hao, Tong Jia-bin, LÜ You, Chong Jia, Tian Wei-meng, LI Peng, DU Xin, MA Chang-sheng and Yang Jie-fu
  
  Abstract Objective: The objective of this study was to develop a new warfarin dosing algorithm based on polymorphisms in CYP2C9 and VKORC1 gene with other demographic variables from a retrospective study for accurate prediction of maintenance dosage in Han subjects with AF in China. Methods: A total of 131 Chinese AF patients with steady warfarin daily dosage (INR reach target range) were recruited from Beijing Hospital during January to November 2011. Blood samples were taken to detect genotype distribution and allelic frequencies of target SNPs: rs1057910 and rs9934438 by direct gene sequencing technique. Demographics variables were recorded during regular visit. All variables for multivariate regression analysis were those significant predictors derived from the univariate analysis, thereafter a stepwise multiple regression analysis was performed to deduce a new dosing algorithm. R.. Read More»
  DOI: 10.4172/2329-9517.1000202

  Abstract PDF