Journal of Nephrology & Therapeutics

Chia-Chao Wu

Publications

• Review Article
  Bone Turnover and Vascular Calcification
  Author(s): Pei-Chen Wu, Cai-Mei Zheng, Min-Tser Liao, Chia-Chao Wu, Kuo-Cheng Lu and Wen-Chih LiuPei-Chen Wu, Cai-Mei Zheng, Min-Tser Liao, Chia-Chao Wu, Kuo-Cheng Lu and Wen-Chih Liu
  
  The impaired bone mineral metabolism followed byVascular Calcification (VC) will be presentat the beginning stage of Chronic Kidney Disease (CKD). VC can be considered as two major types, which are intimal calcification, associated with atherosclerosis, and medial calcification that involves damaged vascular smooth muscle cells (VSMCs), which leads to increase vascular stiffness and decrease vascular elasticity. Many factors control the mechanisms, and they are imbalances in serum calcium and phosphate, systemic inflammation, hyperparathyroidism, increased matrix degradation, VSMC apoptosis, decreased matrix glutamate protein, etc. These will make VSMCs Trans differentiation to phenotypic osteoblastic cells. In addition, patients with CKD usually have bone turnover problems. For a high turnover status, secondary hyperparathyroidism increases calcium and phosphate release from the bone.. Read More»
  DOI: 10.4172/2161-0959.1000171

  Abstract PDF