Journal of Bioanalysis & Biomedicine

Ching Thai

Publications

• Research Article
  Capillary Microsampling of Mouse Blood in Early Pre-Clinical Studies: A Preferred Alternative to Dried Blood Spot Sampling
  Author(s): Jennie Roberts, Ian Wilson, Alan T Henley, Meirion Richards, Ching Thai and Florence I RaynaudJennie Roberts, Ian Wilson, Alan T Henley, Meirion Richards, Ching Thai and Florence I Raynaud
  
  Recent advances in sensitivity of analytical instrumentation has resulted in the routine practice of low-volume blood sampling in pre-clinical pharmacokinetic studies. Mice, the species of choice in oncology, have a limited blood volume; hence demand a small volume sampling strategy to avoid unwanted physiological side effects. When assessing drug exposure in mice, a serial sampling methodology requires less than 20 μl of blood per time point in order to comply with animal welfare guidelines. Various microsampling techniques have been employed in pharmacokinetic studies to achieve exact sampling of low blood volumes. The aim of this work was to explore capillary microsampling as an alternative methodology to dried blood spot sampling for the analysis of whole blood in mouse pharmacokinetic studies. Concentration-time profiles of both blood sampling techniques were compare.. Read More»
  DOI: 10.4172/1948-593X.1000149

  Abstract PDF