Cardiovascular Diseases & Diagnosis

Christian Machado

Publications

• Research Article
  Assessing the Prevalence of Mechanical Dyssynchrony with Activity in Patients with Low Ejection Fraction and Narrow QRS at Rest
  Author(s): Sachin Kumar Jain, Timothy R. Larsen, Peter Burke, Dustin Feldman and Christian MachadoSachin Kumar Jain, Timothy R. Larsen, Peter Burke, Dustin Feldman and Christian Machado
  
  Introduction: Cardiac Resynchronization Therapy (CRT) improves hemodynamics, symptoms, and overall mortality in patients with advanced heart failure (HF) and ventricular electrical dyssynchrony (QRS duration >120 msec). Previous studies have shown that mechanical dyssynchrony (MD) may be present in up to 45% of patients with advanced HF and QRS duration <120 ms at rest. We determined whether activity induces MD in patients with QRS duration <120 msec. Methods: A total of 47 consecutive patients with left ventricular ejection fraction (LVEF) ≤ 30%, New York Heart Association (NYHA) class II-IV HF, and a QRS complex <120 ms were evaluated for MD at rest and exercise utilizing a modified Bruce protocol and three dimensional echocardiography. Time to peak systolic velocity was measured via Tissue Doppler and MD was defined as a ti.. Read More»
  DOI: 10.4172/2329-9517.1000138

  Abstract PDF