Journal of AIDS & Clinical Research

Christine Durier

Publications

• Research Article
  Long-Term Persistence of Vaccine-Induced HIV Seropositivity in Healthy Volunteers
  Author(s): Corinne Desaint, Christine Durier, Armel Poda, Anne Krivine, François Simon, Hélène Bodilis, Gilles Pialoux, Lise Cuzin, Isabelle Poizot-Martin, Pascale Morineau, Jean-Daniel Lelievre, Benjamin Silbermann, Jean-Pierre Aboulker and Odile LaunayCorinne Desaint, Christine Durier, Armel Poda, Anne Krivine, François Simon, Hélène Bodilis, Gilles Pialoux, Lise Cuzin, Isabelle Poizot-Martin, Pascale Morineau, Jean-Daniel Lelievre, Benjamin Silbermann, Jean-Pierre Aboulker and Odile Launay
  
  Objectives: To assess the long-term serological impact of HIV preventive vaccine trial participation, vaccineinduced HIV seropositivity (VISP) was evaluated and related factors were investigated. The anti-HIV antibody reactivity ratio distribution was estimated. Methods: ANRS COHVAC is an open national prospective multicentre cohort study including healthy volunteers who received at least one dose of vaccine candidate of ANRS HIV preventive vaccine trials since 1992. VISP was studied in a cross-sectional study at the time of the cohort’s initial visit, starting in 2008. Anti-HIV antibody detection was performed using the ABBOTT ARCHITECT® HIV Ag/Ac Combo Enzyme Immunoassay (EIA) in a centralized laboratory. A ratio greater than or equal to 1 was considered to define HIV seropositivity. Results: 293 participants were evaluated for a median period of 6 years (r.. Read More»
  DOI: 10.4172/2155-6113.1000275

  Abstract PDF