Cancer Science & Therapy

Christoph- Thomas Germer

Publications

• Research Article
  Clinical Significance of Disseminated Pluripotent Tumor Cell SignatureExpression in the Bone Marrow from Patients with Colorectal Cancer
  Author(s): Martin Gasser, Mia Kim, Roberta Rehder, Natasha Frank, Markus Frank, Tanja Grimmig, Romana Moench, Carmen Ribas, Bertram Illert, Christoph- Thomas Germer, Andreas Rosenwald and Dr. Ana Maria Waaga-GasserMartin Gasser, Mia Kim, Roberta Rehder, Natasha Frank, Markus Frank, Tanja Grimmig, Romana Moench, Carmen Ribas, Bertram Illert, Christoph- Thomas Germer, Andreas Rosenwald and Dr. Ana Maria Waaga-Gasser
  
  Purpose: Disseminated tumor cells (DTCs) are critically involved in tumor relapse and survival in several invasive tumors. We previously showed that the ATP-binding cassette (ABC) transporter, ABCB5, is a chemoresistance mediator expressed on specific cell subsets in colorectal cancer (CRC) and other malignancies. This study evaluated the molecular signature expression and its clinical relevance of DTCs in bone marrow from patients with colon cancer. Methods: This study included 49 consecutive patients (UICC stage I-IV) that underwent curatively intended or palliative surgery for CRC. We analyzed cells from bone marrow aspirates obtained before surgery and derived from patients that had completed minimally a 5-year follow-up. The gene expression of ABCB5 in comparison to CD133 (molecule for identifying cancer initiating cells), Lgr5 (an inte.. Read More»
  DOI: 10.4172/1948-5956.1000490

  Abstract PDF