Fraunhofer Institute for Cell Therapy and Immunology,
Perlickstraße 1, 04103 Leipzig
Germany
Research Article
Decorin in Orbital Fibroblasts as a Possible Target in the Pathogenesis of Graves' Ophthalmopathy
Author(s): Heinig L, Manthe K and Christopher OelkrugHeinig L, Manthe K and Christopher Oelkrug
Background: The initiation of Graves’ ophthalmopathy (GO), an orbital manifestation of Graves’ disease (GD), still remains unclear. Whether thyroid stimulating hormone receptor (TSHr) plays a pivotal role is still debatable. In context, fibroblast-derived proteins are currently under intense consideration.
Results: Current study was designed to evaluate whether decorin, a 38 kDa proteoglycan, could be a plausible target in the pathogenesis of GO utilising in silico methods for protein and sequence analysis. This fibroblast-derived protein is known to have conserved leucine rich repeats (LRR) and is constitutively expressed in fibroblasts and tissues of mesenchymal origin, unlike TSHr. Furthermore, decorin expression in orbital fibroblasts (OF), the target tissue implicated in GO, has not been investigated yet.
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