International Journal of Neurorehabilitation

Cisari Carlo

Publications

• Research Article
  Functional MRI with Motor Imagery Task Show CNS Effects and Brain Plasticity after Botulinum Toxin Therapy in Spastic Hemiplegic Stroke Patients
  Author(s): Stecco Alessandro, Matheoud Roberta, Perchinunno Marco, Carda Stefano, Fortunelli Lorenzo, Marini Federica, Cisari Carlo and Carriero AlessandroStecco Alessandro, Matheoud Roberta, Perchinunno Marco, Carda Stefano, Fortunelli Lorenzo, Marini Federica, Cisari Carlo and Carriero Alessandro
  
  Introduction: Botulinum toxin is considered a first-line treatment for focal spasticity after stroke, and its peripheral effects have been well documented. We set out to demonstrate and describe any effects it may have in the central nervous system, using fMRI to record brain activation patterns before and after its administration. Materials and Methods: 17 subjects comprising 7 ischemic stroke patients affected by upper limb spastic hemiplegia, and 10 healthy controls were recruited and underwent three fMRI scans while performing a motor imagery task (finger tapping). Test subjects underwent fMRI before botulinum toxin therapy (T0), 4 weeks later (T1), and after 8 weeks (T2), and untreated control subjects were tested at 0, 4 and 8 weeks. The finger-tapping task was performed twice each session in both groups. Both test and control subjects pe.. Read More»
  DOI: 10.4172/2376-0281.1000104

  Abstract PDF